Phase II/III trial of hyperimmune anti-COVID-19 intravenous immunoglobulin (C-IVIG) therapy in severe COVID-19 patients: study protocol for a randomized controlled trialArticle Published on 2022-11-082022-11-16 Journal: Trials [Category] SARS, 변종, [키워드] adaptive anti-COVID-19 IVIG antivirals clinical evidence clinical trial collected convalescent convalescent plasma COVID-19 cumulative death Efficacy eligibility criteria evaluate Health hyperimmune immunization immunomodulators intravenous Intravenous immunoglobulin low dose monoclonal antibodies Neutralizing non-specific novel Novel coronavirus outcome Passive passive immunization Patient phase Pneumonia polyclonal polyclonal antibodies Pooled convalescent plasma Potential treatment Randomized Randomized controlled trial receive Recovered COVID-19 patients reported SARS CoV-2 SARS CoV-2. SARS-CoV-2 sealed Secondary outcomes severe COVID-19 severe COVID-19 patient severe COVID-19 patients Standard of care Steroids Study protocol therapeutic option therapy treat Treatment Trial variant variants of concern virus virus particles World Health Organization [DOI] 10.1186/s13063-022-06860-2 PMC 바로가기
Reconstructed Genome-Scale Metabolic Model Characterizes Adaptive Metabolic Flux Changes in Peripheral Blood Mononuclear Cells in Severe COVID-19 PatientsArticle Published on 2022-10-172022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome adaptive aerobic Analysis anti-inflammatory effect antiviral drugs biogenesis caused change changes in Coronavirus disease 2019 Coronavirus-2 COVID-19 differentially expressed enzyme FASN fatty flux Glycolysis Health Immune cell Inflammation Inflammatory lipids mechanism metabolic metabolic model metabolism metabolism-directed therapy. metabolites Model mononuclear cell nucleotide oxidative phosphorylation pathogenic PBMC PBMCs peripheral Peripheral blood potential therapeutic targets provide reaction reconstructed Regulation responsible retinol SARS-CoV-2 severe COVID-19 patients SLC2A3 therapy Transcriptome Treatment Vitamin [DOI] 10.3390/ijms232012400 PMC 바로가기
TIMELESS is a key gene mediating thrombogenesis in COVID-19 and antiphospholipid syndromeArticle Published on 2022-10-142022-11-15 Journal: Scientific Reports [Category] 유전자 메커니즘, 진단, [키워드] Analysis analysis antibody autoantibody autophagy gene Bioinformatics analysis Cell circadian clock Coagulation contribute COVID-19 COVID-19 patient COVID-19 patients Critically ill cytoHubba Cytoscape software dataset Differentially expressed genes evaluated expression Genes Genetic GSK3B identify Immune-mediated Immunotherapy increased risk Interference investigated Kyoto mechanism Mild Modification mononuclear cell ontology term pathway Patient patients protein-protein interaction Proteins regulate severe COVID-19 severe COVID-19 patient severe COVID-19 patients severity suggested Symptom syndrome therapeutic potential thrombosis Transcriptome were used with COVID-19 [DOI] 10.1038/s41598-022-21694-3 PMC 바로가기
Comparative efficacy and safety of pharmacological interventions for severe COVID-19 patients: An updated network meta-analysis of 48 randomized controlled trialsArticle Published on 2022-10-142022-11-15 Journal: Medicine [Category] meta-analysis, 진단, [키워드] Abstract ACM all-cause mortality Characteristics Colchicine Comparative convalescent plasma database decrease dosage effective Efficacy and safety hyperimmune Imatinib Immunoglobulin Intravenous immunoglobulin medication Methylprednisolone Network meta-analysis Older participant Patient pharmacological intervention Placebo Randomized controlled trial RCT RCTs Remdesivir Safe sarilumab searched severe COVID-19 Severe COVID-19 Infection severe COVID-19 patients suggested TEAE TEAEs treatment-emergent adverse event Trial [DOI] 10.1097/MD.0000000000030998 PMC 바로가기
Galectin-3 binding protein stimulated IL-6 expression is impeded by antibody intervention in SARS-CoV-2 susceptible cell linesArticle Published on 2022-10-112022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, [키워드] Activation affected antibody binding cell line cell types Colon contribute COVID-19 COVID-19 patients described disease epithelial expression galectin-3 global pandemic identify IL-6 IL-6 expression inflammatory cells Intervention lung epithelial marker monoclonal antibody pathophysiology pro-inflammatory cytokine Protein receptor Research SARS-CoV-2 severe cases severe COVID-19 patients severe disease severity stimulate stimulated susceptible cell the cytokine storm therapeutic targets Treatment was reduced [DOI] 10.1038/s41598-022-20852-x PMC 바로가기
Central and effector memory T cells in peripheral blood of patients with interstitial pneumonia: preliminary clues from a COVID-19 studyArticle Published on 2022-10-102022-11-15 Journal: Respiratory Research [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute phase addition affected Analysis biological marker CD3+ cells CD4 CD8 Cell cell population central memory Central memory T cells control group control patient controls COVID-19 COVID-19 diagnosis cross-sectional decrease described differential expression disease early phase effector effector memory Effector memory T cells flow cytometry group homeostasis hospital Hospital admission immune increase interstitial interstitial lung involvement interstitial pneumonia lymphocyte subpopulation Lymphocyte subpopulations memory memory T memory T cells Patient patients with pneumonia performed Peripheral blood peripheral lymphocyte Pneumonia positive pre-existing T-cell protocol reactivity recruited Research Respiratory disease SARS-CoV-2 SARS-CoV-2 PCR SARS-CoV-2. severe COVID-19 patients significant decrease significant increase study participant study period subpopulations subset T cell T-cell therapeutic viral respiratory infections were assessed [DOI] 10.1186/s12931-022-02190-8 PMC 바로가기
Comparative Upper Respiratory Tract Transcriptomic Profiling Reveals a Potential Role of Early Activation of Interferon Pathway in Severe COVID-19Article Published on 2022-10-012022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] Acute respiratory infection Comparative Coronavirus disease 2019 COVID-19 COVID-19 negative COVID-19 patient COVID-19 patients death driving evaluated Genes Host transcriptional response host-pathogen interactions IFN-I IFN-I response Inflammation initial symptom interferon involved ISG ISGs lung mechanism Mild OAS Potential Profiling progression respiratory Respiratory failure RNA-Seq RNA-sequencing role SARS-CoV-2 severe COVID-19 patient severe COVID-19 patients severe symptom stimulated symptomatic patient the disease tract type I interferon upper upper respiratory tract upregulated viral infection Viral infection. Viral load [DOI] 10.3390/v14102182 PMC 바로가기
Single-cell transcriptome analyses reveal distinct gene expression signatures of severe COVID-19 in the presence of clonal hematopoiesisArticle Published on 2022-10-012022-11-16 Journal: Experimental & Molecular Medicine [Category] 변종, 유전자 메커니즘, [키워드] analysis ChIP chromatin chromatin architecture classical monocytes clinical impact COVID-19 dissect element exacerbating exhibited facilitate Gene Expression gene expression signature Hematopoiesis highlight hyperinflammation IFN-γ immunological individual Inflammation inflammatory immune response Inflammatory responses interactions mechanism methylated mononuclear cells Patient Peripheral blood putative target gene Region Regulatory reported severe COVID-19 severe COVID-19 patients severity single-cell susceptibility Transcriptome with COVID-19 [DOI] 10.1038/s12276-022-00866-1 PMC 바로가기
Persistent but dysfunctional mucosal SARS-CoV-2-specific IgA and low lung IL-1β associate with COVID-19 fatal outcome: A cross-sectional analysisArticle Published on 2022-09-292022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome addition Antibody Response Antigen BAL Bronchoalveolar lavage clearance coronavirus coronavirus disease COVID-19 cross-sectional analysis domain fatal COVID-19 function IgA IgG IL-1β immune complex Infection Inflammatory Inflammatory cytokine lung mucosal mucosal immunity neutralization Neutralizing activity Neutralizing titer nucleocapsid protein outcome Patient persistent Protective RBD RBD variants reduced replicate SARS-CoV-2 SARS-CoV-2-specific antibody severe COVID-19 patients Severe infection severe infection. Survivors tested viral clearance virus virus virus elimination with COVID-19 Wuhan [DOI] 10.3389/fimmu.2022.842468 PMC 바로가기
CGRP Plasma Levels Correlate with the Clinical Evolution and Prognosis of Hospitalized Acute COVID-19 PatientsArticle Published on 2022-09-262022-11-15 Journal: Viruses [Category] SARS, 바이오마커, [키워드] baseline Biomarker blood sample calcitonin calcitonin gene-related peptide (CGRP) clinical clinical disease Coagulopathy collected correlated correlation COVID-19 Critical diagnosed disease disease severity eligible etiological agent Evolution heterogenous higher risk highlighting Hospitalization Hospitalized hyperinflammation immune modulation In-hospital investigated involved IP10 Italian Laboratory test Level lung majority moderate pandemic pathophysiology Patient peptide performed plasma predicted prospective cohort study pulmonary intravascular coagulopathy. SARS-CoV-2 SARS-CoV-2 patient severe COVID-19 patients severe respiratory failure Stratification Support Vasoactive [DOI] 10.3390/v14102123 PMC 바로가기